In-vitro and in-vivo illumination

In Vitro and In Vivo illumination

Modulight provides a versatile and comprehensive product family for in-vitro and in-vivo illumination. Modulight lasers are used in many cell research laboratories worldwide to study photodynamic therapy (PDT). PDT utilizes photosensitizers that can be activated with specifically designed light sources – reactive oxygen is created at the target due to light activation.

Photosensitizers are also used in targeted drug delivery, and light activation is used for releasing the drug from the cargo. The PDT is on the verge of bringing another revolutionizing tool to be used in the treatment of glioblastoma, uveal melanoma, bile duct, pancreatic, and many other cancers.

Modulight’s in-vitro and in-vivo product family enables illumination of anything. We make lasers with variety of wavelengths, ranging from 400 to 2000 nm. Thus, we can support the research of all existing photosensitizers.

Our product offering: from In Vitro to Clinic with Modulight lasers

In Vitro
In Vitro
In Vitro
In Vivo
Clinical
Clinical

Application Notes and Articles by Our Customers

Protected: Multimodal imaging microscope for tissue engineering applications

Customer case Research by: Computational biophysics and imaging research group at Tampere University. Research topics include development of bioimaging, analysis and biophysics based in-silico tools for new personalized treatments and diagnostics. Modulight products: ML6600 (488, 561, and 635 nm) Laser use: Light source for multimodal 3D imaging microscope used for imaging tissue engineering processes and products.   Professor Jari Hyttinen     Link to the study:   Toni Montonen, Doctoral Researcher   Motivation for the study Tissue engineering is an evolving field of medicine that aims Continue reading →

Light delivery optimization for H&N cancer treatment

Customer case Roswell Park Comprehensive Cancer Center was founded in 1898 as the first institute in the US devoted exclusively to cancer treatment and research. It is also the place where photodynamic therapy (PDT) was developed in the late 1970s by Thomas Dougherty. The PDT center at Roswell Park is a leader in the use of photodynamic therapy for treating different cancers. Research work includes treatment planning and light dosimetry for interstitial and intraoperative PDT to improve the quality of life and survival of cancer patients Continue reading →

Antimicrobial PDT for prosthetic joint infections

Customer case Royal National Orthopaedic Hospital at UCL, Stanmore in London, UK is an internationally leading Centre of Excellence and tertiary referral centre for complex orthopedic conditions. Close collaboration between clinicians and engineers facilitates high-quality research into orthopedic implant fixation and bone regeneration. Focus is on translational themes that include biomaterials, stem cells, the design and follow-up of implants, bone graft substitute materials and implant infections. PDT has been studied as an alternative to antibiotics to more effectively tackle infections following hip & knee replacement Continue reading →

Watch video about Modulight's In Vitro / In Vivo Solutions

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Essential products for in vivo, in vitro, and preclinical applications

ML8500 – automated biomedical illumination device – provides targeted illumination for microplates. Each well is automatically and sequentially illuminated with a specific dose, irradiance and wavelength. Environmental parameters, like carbon dioxide content and temperature, can be adjusted. Optional fluorescence monitoring and cell imaging are also available. ML8500 supports various microplates (24/96/384/1536) and petri dishes. Illumination programs can be created remotely, and collecting data from the cloud can be conveniently done from the office – no need to control the illumination at the lab. Cloud connection enables also the remote support, service, and upgrades.

ML7710 is the most versatile oncology laser system for PDT studies, and the same product can be used for in-vitro/vivo studies and clinical therapies (CE mark, FDA approval for some combination therapies). The ML7710 is a cost-effective solution for long-term study plan including pre-clinical and clinical phases – using the same device from first phase studies to clinical tests makes regulatory work faster. The ML7710 is used already in many clinics and in well-known cancer centers worldwide. We provide internet connectivity, remote diagnostics, cloud services, and low-cost upgrades.

Modulight Illumination Kit is a series of accessories that enable uniform, parallel illumination of petri dishes and well plates. The whole sample plate is illuminated simultaneously in a specially designed illumination chamber. The laser light source can be an ML7710, or very compact but powerful ML6500 and ML6600 laser modules. ML6500 enables the use of one wavelength and ML6600 up to 3 wavelengths.  These laser sources can be used together with different light delivery options, e.g., SMA connected fiber with a frontal diffuser at the end. Most popular option among in vitro studies is to have our Illumination Kit sample stage that enables illumination of the well plate.

Modulight provides also many different and customized sample stage designs which can be tailored to fit any illumination target. We provide support for dose calculation and calibration, and our lasers have simple graphical user interfaces or they can be controlled from the computer. Products are supported with full suite of services from calibration to on-site training.

Illumination solution can be customized to your needs:

  • Wavelength can be selected between 400 – 2000 nm
  • Irradiance and dose can be adjusted
  • Different sample stages supporting the use of microplates, petri dishes, and possibility for customized
  • Handpiece enables in vivo subcutaneous illumination, option for spot size adjustment
  • We provide many different medical fiber options
  • Controlled and repeatable illumination, support for dose calculation
  • Possibility to use 1-8 different wavelengths
  • Pulsing possible in ms – µs range
  • On-site training
  • Regular calibrations and device support

In-vitro and in-vivo customer referrals

Poul Martin Bendix, PhD, Associate Professor at Niels Bohr Institute

Sherri McFarland, PhD, Professor at University of Texas at Arlington (Formerly Professor at The University of North Carolina at Greensboro)

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