Customer case PCI Biotech is a biopharmaceutical company located in Norway. They are developing a novel light based technology called photochemical internalization (PCI) that has potential to enhance delivery and efficacy of many types of therapies, including certain chemotherapies, peptide vaccines, and nucleic acid therapies. It can also decrease side effects thanks to improved spatiotemporal control of the treatment. The technology is currently in a pivotal clinical study for the treatment of inoperable bile duct cancer where PCI with gemcitabine is combined with standard gemcitabine/cisplatin Continue reading →

Customer case University of Rochester belongs among nation’s top research universities. Research at the Baran lab focuses on anti-microbial PDT and optical image processing. Aim is to develop methods for utilizing quantitative information from CT, MR and PET imaging for PDT treatment planning as well as in the search of new biomarkers and therapeutic targets. Modulight products: ML7710 (630 & 665 nm) Link to the study: Timothy M. Baran (Ph.D., PI) Laser use: Ongoing clinical Phase 1 safety & feasibility study for methylene blue mediated Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – November 2021 Dr. Aaron Sorrin and researchers at the University of Maryland found a new potential combination therapy for ovarian cancer. This combination includes a novel light-based technology, called photodynamic priming, and a targeted therapeutic against a specific cancer cell receptor, effectively suppressing invasion of cancer cells. Modulight’s scientific board wanted to highlight this research especially because novel therapeutic solutions are urgently needed against this aggressive disease, which despite the best possible current therapies, recurs in most patients leading to Continue reading →

Customer case University of California at Irvine (UCI), founded in 1965, is a top 10 public university in USA. It is recognized for cutting-edge and innovative scientific research. Modulight products: ML7710 (689 nm) Laser use: Targeted phototherapy studies with photo-immunoconjugates Link to the study: Nzola De Magalhães, Adjunct Assistant Professor   Motivation for the study Efficient light delivery to the whole tumor is one of the main aspects of phototherapy. The efficacy of phototherapy has been demonstrated for several cancers via superficial illumination. Interstitial illumination could Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – October 2021 This time we wanted to highlight Professor Tebello Nyokong’s team at Rhodes University, since their latest research tackles two big unmet needs in cancer therapy: tumor hypoxia and side effects of the drugs. The team designed multifunctional liposomes that can locally generate oxygen within tumors to alleviate hypoxia, which is a significant contributor to resistance to radio- and chemotherapies. These nanodrugs also hold the potential to reduce problematic side effects of standard cancer therapies as a result of Continue reading →

Customer case Research by: University of Maryland, Optical Therapeutics & Nanotechnology Laboratory led by Prof. Huang. Research focuses on precision cancer nanomedicine, drug delivery strategies, overcoming cancer resistance, mechanism-based combination therapies, site-directed photochemistry and fluorescence diagnostics. Modulight has started a joint R&D program with Dr. Huang lab to study novel EGFR-targeted combination therapy/diagnostic agent PIC-Nal-IRI developed by Huang lab. Modulight products: ML6600 laser system (635 nm and 689 nm). Professor Huang-Chiao Huang Laser use: Targeted photodynamic therapy/photoimmunotherapy with benzoporphyrin derivative (BPD) & 5-aminolevulinic acid (5-ALA) photosensitizers. Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – September 2021 Laser-Sharp Research nomination goes to this month for Professor Kobayashi’s team and Dr. Noriko Sato’s team at National Cancer Institute, National Institute of Health, USA. Their research published in a prestigious Cancer Research journal showed that photoimmunotherapy can not only target tumor cells, but can also be harnessed to target body’s own tumor-promoting immune cells within the tumor. These special cells called intratumoral Tregs were selectively killed by photoimmunotherapy upon illumination with ML7710 laser, which led to activation Continue reading →

Customer case Research by: Computational biophysics and imaging research group at Tampere University. Research topics include development of bioimaging, analysis and biophysics based in-silico tools for new personalized treatments and diagnostics. Modulight products: ML6600 (488, 561, and 635 nm) Laser use: Light source for in-house built multimodal 3D imaging microscope used for imaging tissue engineering processes and products.   Professor Jari Hyttinen     Link to the study:   Toni Montonen, Doctoral Researcher     Motivation for the study Tissue engineering is an evolving field of Continue reading →