Modulight Spotlights: LASER-SHARP RESEARCH – July 2022 Modulight congratulates Dr. Makoto Mitsunaga et al. @Jikei University School of Medicine for publishing their promising results in Communications Biology journal. The team developed a next-generation light-based approach to tackle pathogens, called photoimmuno-antimicrobial strategy (PIAS). This technology was shown to eliminate a broad spectrum of different classes of pathogens, such as viruses, fungi, and bacteria. Unlike antibiotics, PIAS was also effective against drug-resistant pathogens and didn’t damage natural, beneficial microbiota in the host’s tissues. As COVID-19 pandemic and Continue reading →

Introduction Flow cytometry is a widely used method in biomedical research and increasingly also in clinical diagnostics. It is a powerful and rapid technique to analyze physical and chemical properties of single cells or particles as they are suspended in liquid and pass in a narrow line across laser beams. Fluorescence together with scattered laser light is then filtered, detected, and analyzed on the other side of the sample. In addition to analysis, many flow cytometers can also sort and purify cell populations of interest Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – February 2022 Photocure’s blue light cystoscopy is a routine procedure in the management of bladder cancer as it results in better tumor visualization and removal. However, this study found that the positive effects of blue light cystoscopy could extend beyond visualization and result in the induction of systemic antitumor immunity, which can be further boosted with immune checkpoint inhibitors. Modulight nominated this study because bladder cancer is highly recurring and progressive disease with more than 200,000 deaths worldwide annually. Thus, Continue reading →

Customer case PCI Biotech is a biopharmaceutical company located in Norway. They are developing a novel light-based technology called photochemical internalization (PCI) that has potential to enhance delivery and efficacy of many types of therapies, including certain chemotherapies, peptide vaccines, and nucleic acid therapies. It can also decrease side effects due to improved spatiotemporal control of the treatment. The technology is currently in a pivotal clinical study for the treatment of inoperable bile duct cancer where PCI with gemcitabine is combined with standard gemcitabine/cisplatin chemotherapy. Continue reading →

Customer case University of Rochester belongs among the nation’s top research universities. Research at the Baran lab focuses on anti-microbial PDT and optical image processing. The aim is to develop methods for utilizing quantitative information from CT, MR and PET imaging for PDT treatment planning as well as in the search of new biomarkers and therapeutic targets. Modulight products: ML7710 (630 & 665 nm) Link to the study: Timothy M. Baran (Ph.D., PI) Laser use: Ongoing clinical Phase 1 safety & feasibility study for methylene Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – November 2021 Dr. Aaron Sorrin and researchers at the University of Maryland found a new potential combination therapy for ovarian cancer. This combination includes a novel light-based technology, called photodynamic priming, and a targeted therapeutic against a specific cancer cell receptor, effectively suppressing invasion of cancer cells. Modulight’s scientific board wanted to highlight this research especially because novel therapeutic solutions are urgently needed against this aggressive disease, which despite the best possible current therapies, recurs in most patients leading to Continue reading →

Customer case University of California at Irvine (UCI), founded in 1965, is a Top 10 public university in USA. It is recognized for cutting-edge and innovative scientific research. Modulight products: ML7710 (689 nm) Laser use: Targeted phototherapy studies with photo-immunoconjugates Link to the study: Nzola De Magalhães, Adjunct Assistant Professor   Motivation for the study Efficient light delivery to the whole tumor is one of the main aspects of phototherapy. The efficacy of phototherapy has been demonstrated for several cancers via superficial illumination. Interstitial illumination could Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – October 2021 This time we wanted to highlight Professor Tebello Nyokong’s team at Rhodes University, since their latest research tackles two big unmet needs in cancer therapy: tumor hypoxia and side effects of the drugs. The team designed multifunctional liposomes that can locally generate oxygen within tumors to alleviate hypoxia, which is a significant contributor to resistance to radio- and chemotherapies. These nanodrugs also hold the potential to reduce problematic side effects of standard cancer therapies as a result of Continue reading →