Lasers are used in ophthalmology more than in any other medical specialty. The transparent nature of human eye makes it possible to target intraocular structures without the need for endoscopy or separate surgery. Ophthalmic applications for which lasers are used range from refractive surgery to treatment of macular diseases and choroidal neovascularization. Modulight diode lasers and complete laser systems are used for many of these applications.
Modulight has taken a mission to support ophthalmology with game changing lasers utilizing possibilities of connectivity via IoT. Modular device concepts allow configurability e.g., for the laser wavelength per application, such as 689 nm in photodynamic therapy (PDT) or 810 nm in transpupillary thermotherapy (TTT) and hence support for multiple medical indications with one approved hardware platform. Modulight ophthalmic laser systems benefit from the strong semiconductor laser knowhow and in-house laser manufacturing capabilities that are truly unique in ophthalmic laser market.
Age-related macular degeneration
Choroidal neovascularization (CNV) means the growth of new, leaky blood vessels that originate from the choroid layer of the eye and grow into the retina. This happens when retinas of patients with dry age related macular degeneration (AMD) produce excess vascular epithelial growth factor (VEGF) encouraging the growth of these vessels. The leakiness of these new blood vessels cause vision loss and treatment options include anti-VEGF drugs or photodynamic therapy.
In photodynamic therapy for AMD, red 689 nm laser light is delivered to the retina in a controlled manner to activate a drug that has accumulated to these abnormal blood vessels. The combination of a nonthermal laser light and a photosensitive drug results in local damage of endothelium and blood vessels helping to restore the vision loss.
CASE: Bringing AMD lasers to this decade
Modulight was selected to become the exclusive laser supplier of Bausch+Lomb to provide them novel ophthalmic lasers to be used with their pharmaceutical compound. Modulight developed a modern medical laser based on ML6600 laser technology which is wirelessly controlled from a tablet, internet connected and operation happens smoothly from an iOS-based graphical user interface.
Ocular or uveal melanoma is the most common intraocular cancer in adults and it is a disease where malignant cells are found from uvea. Most uveal melanomas originate from the choroid and can also be called choroidal melanomas. Choroidal melanomas might show as blurry vision or present no symptoms at all before they are at quite advanced stage. Treatment options for choroidal melanomas are very limited and primary treatment option might even involve enucleation, which removal of the eye.
Novel clinical studies are investigating the application of Virus-Like Drug Conjugate (VDC) technology to uveal melanoma. This presents a possibility for minimally invasive laser-based treatment option also for choroidal melanoma patients.
CASE: Ophthalmic oncology laser for clinical trials
Customer needed a laser for initial clinical studies that is quickly available and complies with all necessary regulatory requirements. Modulight provided an initial solution based on the ophthalmic configuration of the ML7710 laser platform to support early clinical activities. Later the technology was moved to more sophisticated form factor.
Single-wavelength ophthalmic laser system for AMD and ocular melanoma. Laser is wirelessly controlled from an iPad and cloud connected to enable remote support. ML6710i is compatible with ophthalmic microscopes, Haag-Streit™ slit lamps and Modulight beam shaping unit ML-SLA.
Modulight ML7710 is multi-wavelength laser system suitable for multiple ophthalmic indications and supports wavelengths between 400-2000 nm. ML7710 ophthalmic configuration includes an interface for ophthalmic microscope, slit lamp, and Modulight beam shaping unit ML-SLA.
Modulight slit lamp adapter –or a laser beam shaping unit produces an excellent beam profile that allows homogenous illumination of the targeted area in the human eye. The spot diameter can be adjusted from 0,5 mm to up to 20 mm with a contact lens. This is a range beyond compare.