Tag Archives: immunotherapy

Modulight Spotlights: LASER-SHARP RESEARCH – August 2023

August 24, 2023 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – August 2023 Interleukin 15 (IL-15) is promising candidate for cancer immunotherapy, since it is an inducer of differentiation and proliferation of killer T cells and NK cells. A new study by Fukushima et al. at NCI, published in Molecular Cancer Therapeutics, shows increase in therapeutic efficacy in vivo when IL15 was combined with photoimmunotherapy using ML7710 laser system. Intratumoral injection of IL-15 also boosted the immune responses against both the primary tumor as well as abscopal effect eradicating distant, untreated tumor.​ ​​ Read original publication Modulight Continue reading →

Intratumoral interleukin-15 improves efficacy of near-infrared photoimmunotherapy

July 18, 2023 by Modulight Content
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Published in: Molecular Cancer Therapeutics Authors: Hiroshi Fukushima, Aki Furusawa, Takuya Kato, Hiroaki Wakiyama, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi    Published in: Molecular Cancer Therapeutics Authors: Hiroshi Fukushima, Aki Furusawa, Takuya Kato, Hiroaki Wakiyama, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi   Interleukin 15 (IL-15) is inducer of differentiation and proliferation of CD8+ T cells and NK cells and thus promising candidate for cancer immunotherapy. This study showed therapeutic efficacy increase in vivo when IL15 was combined with cancer cell-targeted photoimmunotherapy using ML7710 laser system. Intratumoral injection of IL-15 was more effective than intraperitoneal in suppressing tumor growth and inducing intratumoral immune responses, Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – April 2023

April 13, 2023 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – April 2023 Metastases remain the leading cause of cancer-related deaths worldwide. To combat this problem, Ruben V. Huis in ‘t Veld et al. combined immune checkpoint inhibitors with a light-activated virus-drug conjugate in their preclinical study. As published in Cancer Immunology, Immunotherapy journal, the combination was effective against metastatic tumors and in most cases even resulted in complete responses to therapy. ​​ Read original publication   Modulight is very happy to be supporting this research. We would like to deliver our Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – October 2022

October 18, 2022 by Modulight Content
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   Modulight Spotlights: LASER-SHARP RESEARCH – October 2022 This month’s laser sharp nomination goes to Takuya Osada‘s team at Duke University Medical Center. Their impressive results on novel immunotherapy combination strategy for breast cancer was published in the Journal for ImmunoTherapy of Cancer. The team combined immune checkpoint blockage with HSP90-targeted light therapy using ML7710 medical laser. This combination resulted in strong activation of antitumor immunity and prolonged survival in syngeneic breast cancer models. Impressively, adding immune checkpoint blockers even resulted in an increased antitumor activity elsewhere, outside the local light-treated area, showing potential Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – September 2021

October 1, 2021 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – September 2021 Laser-Sharp Research nomination goes to this month for Professor Kobayashi’s team and Dr. Noriko Sato’s team at National Cancer Institute, National Institute of Health, USA. Their research published in a prestigious Cancer Research journal showed that photoimmunotherapy can not only target tumor cells, but can also be harnessed to target body’s own tumor-promoting immune cells within the tumor. These special cells called intratumoral Tregs were selectively killed by photoimmunotherapy upon illumination with ML7710 laser, which led to activation Continue reading →

Light-emitting fabrics for dermatological diseases

June 26, 2021 by Modulight Content
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    Related Modulight products and Services   Related Publications Light emitting fabrics for PDT: technology and results of clinical studies Serge R. Mordon, Elise Thecua, Fabienne Lecomte, Anne-Sophie Vignion-Dewalle, Pascal Deleporte, Cyril Maire, Henry Abi-Rached, Claire Vicentini, Theresa Hommel, R. Markus Szeimies, Laurent Mortier SPIE, 2019   Photodynamic Therapy Using a New Painless Light-Emitting Fabrics Device in the Treatment of Extramammary Paget Disease of the Vulva (the PAGETEX Study): Protocol for an Interventional Efficacy and Safety Trial Fabienne Lecomte, Elise Thecua, Laurine Ziane, Pascal Continue reading →Customer case Research by: Laser-assisted therapies and immunotherapies for oncology (OncoThAI) center at University of Lille is a large research center that carries fundamental and translational projects with the aim to widely implement PDT to clinical use either alone or in combination with other therapies like surgery or immunotherapy. Modulight products: ML7710 (631, 635, 665 nm) Laser use: Light-emitting fabrics for PDT therapy at clinical level   Prof. Serge Mordon PhD, currently at BioTis/Inserm     Dr. Laurent Mortier, MD, PhD, University of Lille   Research Continue reading →

Rising star in immunotherapy

September 15, 2015 by Seppo Orsila
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San Jose, California & Tampere FINLAND, September 15, 2015 – Modulight, Inc., a leading biomedical laser manufacturer, announces today a rising star in immunotherapy competition. The objective is to help clinicians and biomedical researchers below 35 years old to get their hands on the best possible tools to support photo immunotherapy. All clinicians, residents and biomedical researchers worldwide are eligible to participate the contest by submitting their application via web (research plan, CV and publication list). Final selection of the winner will be done by an independent board of Continue reading →