Tag Archives: flow cytometry

AI-based laser alignment for Flow Cytometry

April 4, 2024 by Modulight Content
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Next generation flow cytometry Lasers have been historically the key light sources utilized in flow cytometry due to their ability to deliver the precise amount of energy needed to trigger the Stokes shift, which is the key phenomena underlying flow cytometry operation. For the same reason lasers and optical system in general are referred to as the “heart of flow cytometer”, since they are the integral component initiating the instrument operation. To ensure smooth and repeatable flow cytometer performance laser source needs to exhibit excellent Continue reading →

Hyperspectral imaging for flow cytometry

January 28, 2024 by Modulight Content
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Published in: SPIE BIOS 2024 Authors: Anna Filipchuk, Robert Perttilä, Ana Colucci, Petteri Uusimaa  Published in: SPIE BIOS 2024 Authors: Anna Filipchuk, Robert Perttilä, Ana Colucci, Petteri Uusimaa Flow cytometry is a widely used analysis technique in biomedical sciences. It has found extensive utilization in both clinical diagnostics and cutting-edge biological research. As the method has been gaining greater recognition, its underlying technologies have undergone rapid development to further expand its range of applications. A notable trend is the introduction of imaging modalities to flow cytometry to expand the information content of the analyzed sample.   Read the article Continue reading →

High-power VECSEL with intracavity UV generation for flow cytometry applications

January 28, 2024 by Modulight Content
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Published in: SPIE BIOS 2024 Authors: Kostiantyn Nechay, Robert Perttilä, Anna Essaulova, Petteri Uusimaa  Published in: SPIE BIOS 2024 Authors: Kostiantyn Nechay, Robert Perttilä, Anna Essaulova, Petteri Uusimaa Flow cytometry is a powerful tool allowing to perform high-dimensional cell analysis which relies on a set of lasers for fluorochrome excitation. Typical flow cytometer employs excitation laser sources at violet, green, green-yellow and red wavelengths, with an extension to UV and DUV spectral bands in order to increase the number of cell characteristics. UV laser source constitutes the single most expensive component of flow cytometers. In this work we present Continue reading →

Modulight launches ML6600 for Flow Cytometry and Quantum Computing

January 14, 2024 by Modulight Content
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Next week at Photonics West 2024, Modulight will unveil significant new additions to the ML6600 laser solution platform. These new innovations include a specialized laser engine tailored for Flow Cytometry applications, and advanced DBR laser cores designed specifically for the Quantum Computing market. Our #LaserFamily are presenting 11 conference papers plus participating in a technical panel, across the Photonics West conferences BIOS, OPTO, LASE and QUANTUM WEST. You can see the list here. ML6600 for Flow Cytometry – Laser engine with active beam steering The newest product utilizing the ML6600 platform is a specialized laser engine for the Continue reading →Next week at Photonics West 2024, Modulight will unveil significant new additions to the ML6600 laser solution platform. These new innovations include a specialized laser engine tailored for Flow Cytometry applications, and advanced DBR laser cores designed specifically for the Quantum Computing market. Our #LaserFamily are presenting 11 conference papers plus participating in a technical panel, across the Photonics West conferences BIOS, OPTO, LASE and QUANTUM WEST. You can see the list here. ML6600 for Flow Cytometry – Laser engine with active beam steering The newest product utilizing the ML6600 platform is a specialized laser engine for the Continue reading →

Flow cytometry

March 28, 2022 by Modulight Content
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Introduction Flow cytometry is a widely used method in biomedical research and increasingly also in clinical diagnostics. It is a powerful and rapid technique to analyze physical and chemical properties of single cells or particles as they are suspended in liquid and pass in a narrow line across laser beams. Fluorescence together with scattered laser light is then filtered, detected, and analyzed on the other side of the sample. In addition to analysis, many flow cytometers can also sort and purify cell populations of interest Continue reading →Introduction Flow cytometry is a widely used method in biomedical research and increasingly also in clinical diagnostics. It is a powerful and rapid technique to analyze physical and chemical properties of single cells or particles as they are suspended in liquid and pass in a narrow line across laser beams. Fluorescence together with scattered laser light is then filtered, detected, and analyzed on the other side of the sample. In addition to analysis, many flow cytometers can also sort and purify cell populations of interest Continue reading →

Nanobody-targeted photodynamic therapy for the treatment of feline oral carcinoma: a step towards translation to the veterinary clinic

August 2, 2021 by Modulight
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Published in: Nanophotonics Authors: Irati Beltrán Hernández, Guillaume C.M. Grinwis, Alessia Di Maggio, Paul M.P. van Bergen en Henegouwen, Wim E. Hennink, Erik Teske, Jan W. Hesselink, Sebastiaan A. van Nimwegen, Jan A. Mol, Sabrina Oliveira    Published in: Nanophotonics Authors: Irati Beltrán Hernández, Guillaume C.M. Grinwis, Alessia Di Maggio, Paul M.P. van Bergen en Henegouwen, Wim E. Hennink, Erik Teske, Jan W. Hesselink, Sebastiaan A. van Nimwegen, Jan A. Mol, Sabrina Oliveira   Nanobody-targeted PDT was shown in vitro to be suitable and efficient for oral carcinoma, which expresses EGFR. Modulight laser was used as an illumination source to activate PDT. Next aim is to treat cats with oral carcinoma before advancing to human clinic.   Read the article here

ML6600 – Cloud-powered Laser Solution Platform

July 3, 2014 by Modulight
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ML6600 - Cloud-Powered Laser Solution PlatformML6600 is an established product platform, originally launched in 2013. ML6600 can host different laser technologies (diode, fiber, DPSS). Specifications will be tailored to the application. Wavelength in the range from UV to 2+ µm, power from mW up to 100 W, and linewidths down to kHz. Easy-to-integrate light engine ML6600 is a compact, easy-to-integrate laser solution that can be flexibly tailored to various applications, such as Flow Cytometry, Semiconductor Metrology, Quantum Computing, Diagnostics, Genetics, and various medical applications. It’s Continue reading →