Tag Archives: cancer

Light delivery optimization for H&N cancer treatment

Results Illumination with one fiber Some level of tissue heating was observed at all used light intensities. At lower intensities (60-100 mW/cm), less than 5% of the tumor was subjected to >60 ⁰C temperature, a point where irreversible thermal damage will immediately occur (photothermal ablation). At intensities of 150-200 mW/cm, 15-20% of the tumor was at >60 ⁰C temperature. At 400 mW/cm, which is FDA-recommended light irradiance for iPDT, a… READ MORE

Vision-sparing targeted phototherapy for uveal melanoma

Preliminary investigation of AU-011     Related Modulight products and Services   Related Publications Virus-Like Particle-Drug Conjugates Induce Protective, Long-lasting Adaptive Antitumor Immunity in the Absence of Specifically Targeted Tumor Antigens Rhonda C. Kines, Cynthia D. Thompson, Sean Spring, Zhenyu Li, Elisabet de los Pinos, Stephen Monks and John T. Schiller Cancer Immunology Research, 2021, 9 (6)   A Phase 1b/2 Open-label Clinical Trial to Evaluate the Safety and Efficacy… READ MORE

ML7710 for photoimmunotherapy against regulatory T cells in tumors

      Experiments Tumor-bearing mice were randomized into 4 groups: 1) no treatment (control), 2) anti-CD25 full IgG antibody (no light activation), 3) anti-CD25 F(ab’)2 fragment, and 4) anti-CD25 full IgG antibody. NIR light using ML7710 (689 nm, 150 mW/cm2, 50 J/cm2) was administered to group 3 and 4 mice on day 1 (PIT). Tumor volumes were monitored for 21 days and survival of mice for up to 80… READ MORE

ML7710 for fluorescence imaging: Detection of colorectal polyps in humans using c-Met targeted fluorescent peptide

Motivation for the study Polyps are small growths on the inner lining of the colon or rectum, affecting around 1 in 4 people over the age of 50. Certain types of polyps may eventually become cancerous, and colon cancer prevention relies on colonoscopy using white light to detect and remove the polyps. However, small and flat polyps are difficult to detect and frequently missed with this technique. More precise methods… READ MORE

Workshop on photodynamic therapy

Sat 7th Feb 5.30–9 pm Downtown San Francisco Topics • Discuss possible ways for enhancing the dissemination of PDT for cancer therapy – Prof. Gal Shafirstein, Roswell Park CI • Scope of active clinical studies in PDT – Prof. Keith Cengel, Univ. of Pennsylvania • Diagnosis, fluorescence and spectroscopy – Prof. Brian Pogue, Dartmouth College • Is dose planning enough or should we use online treatment monitoring? – Prof. Timothy… READ MORE

Workshop on the best practices in clinical photodynamic therapy

Fri 24th April 6 pm, Gaylord Palms Resort, Kissimmee, FL Workshop presentations Products and accessories on display • ML7710 – CE and ETL marked multi-purpose PDT laser platform • ML6700 – PDT-Illumination laser module tailored to PDT for R&D • ML6600 – Multi-wavelength laser module for PDT • External dose calibration module for PDT lasers NEW • Hand pieces for superficial PDT illumination NEW • Tailored PC software for PDT… READ MORE