Tag Archives: preclinical

Photothermal therapy with platinum nanoparticles

August 16, 2021 by Modulight Content
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Photothermal therapy efficiency Human ovarian cancer cells were plated on Petri dishes and incubated with platinum nanoparticles of varying sizes between 30 and 70 nm. After 24-hour incubation, irradiation was performed using a Modulight ML6600 laser at 808 nm together with an illumination kit (MLAKIT) tailored for Petri dish illumination. A small area of the dish was illuminated with the laser for five minutes with 45 W/cm2 irradiance. Calcein cell… READ MORE

Monitoring tissue responses to vascular-targeted PDT in high resolution

April 28, 2021 by Modulight Content
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  Study protocol         Related Modulight products and Services ML7710 – Laser device suited for pre-clinical and clinical applications »      Related Publications WST11 Vascular Targeted Photodynamic Therapy Effect Monitoring by Multispectral Optoacoustic Tomography (MSOT) in Mice Volker Neuschmelting, Kwanghee Kim, Jaber Malekzadeh-Najafabadi, Sylvia Jebiwott, Jaya Prakash, Avigdor Scherz, Jonathan A Coleman, Moritz F Kircher, Vasilis Ntziachristos Theranostics, 2018, 8 (3)   High-resolution optoacoustic imaging of tissue… READ MORE

In vitro illumination using ML8500: osmium-based anticancer photosensitizer with highest hypoxic activity reported to date

March 26, 2021 by Modulight Content
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  Study protocol to determine wavelength, fluence, and irradiance activities of Os-4T:   Key observations Illumination parameters significantly affected the phototoxicity of Os-4T. Green light (525 nm) was more effective than red light (630 nm) at lower fluences, while maximal potency was achieved at both wavelengths when using fluences higher than 100 J/cm2. Irradiance affected the potency with both red and green light that were more effective when lower irradiances… READ MORE