Modulight Spotlights: LASER-SHARP RESEARCH – September 2021
Tag Archives: preclinical
Photothermal therapy with platinum nanoparticles
Photothermal therapy efficiency
Human ovarian cancer cells were plated on Petri dishes and incubated with platinum nanoparticles of varying sizes between 30 and 70 nm. After 24-hour incubation, irradiation was performed using a Modulight ML6600 laser at 808 nm together with an illumination kit (MLAKIT) tailored for Petri dish illumination. A small area of the dish was illuminated with the laser for five minutes with 45 W/cm2 irradiance. Calcein cell… READ MORE
Uncovering tumor responses to vascular-targeted phototherapy
Study protocol
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ML7710 – Laser device suited for pre-clinical and clinical applications »
Related Publications
WST11 Vascular Targeted Photodynamic Therapy Effect Monitoring by Multispectral Optoacoustic Tomography (MSOT) in Mice
Volker Neuschmelting, Kwanghee Kim, Jaber Malekzadeh-Najafabadi, Sylvia Jebiwott, Jaya Prakash, Avigdor Scherz, Jonathan A Coleman, Moritz F Kircher, Vasilis Ntziachristos
Theranostics, 2018, 8 (3)
High-resolution optoacoustic imaging of tissue… READ MORE
In vitro illumination using ML8500: osmium-based anticancer photosensitizer with highest hypoxic activity reported to date
Study protocol to determine wavelength, fluence, and irradiance activities of Os-4T:
Key observations
Illumination parameters significantly affected the phototoxicity of Os-4T. The green light (525 nm) was more effective than the red light (630 nm) at lower fluences, while the maximal potency was achieved at both wavelengths when using fluences higher than 100 J/cm2. Irradiance affected the potency with both the red and the green light that were… READ MORE