There is no excerpt because this is a protected post.
Motivation for the study The motivation was to study if photoimmunotherapy could enhance anti-tumor immunity when combined with immune checkpoint inhibition. CD44-targeted photoimmunotherapy was applied against poorly immunogenic, “cold” tumor and antitumor effect was studied alone and in combination with anti-PD-1 immune checkpoint inhibition. Sensitization of this “cold” tumor to immune checkpoint inhibition after photoimmunotherapy would mean that the tumor has been converted into highly immunogenic, “hot” tumor infiltrated with… READ MORE
Experiments Tumor-bearing mice were randomized into 4 groups: 1) no treatment (control), 2) anti-CD25 full IgG antibody (no light activation), 3) anti-CD25 F(ab’)2 fragment, and 4) anti-CD25 full IgG antibody. NIR light using ML7710 (689 nm, 150 mW/cm2, 50 J/cm2) was administered to group 3 and 4 mice on day 1 (PIT). Tumor volumes were monitored for 21 days and survival of mice for up to 80… READ MORE