Results Illumination with one fiber Some level of tissue heating was observed at all used light intensities. At lower intensities (60-100 mW/cm), less than 5% of the tumor was subjected to >60 ⁰C temperature, a point where irreversible thermal damage will immediately occur (photothermal ablation). At intensities of 150-200 mW/cm, 15-20% of the tumor was at >60 ⁰C temperature. At 400 mW/cm, which is FDA-recommended light irradiance for iPDT, a… READ MORE
Motivation for the study The motivation was to study if photoimmunotherapy could enhance anti-tumor immunity when combined with immune checkpoint inhibition. CD44-targeted photoimmunotherapy was applied against poorly immunogenic, “cold” tumor and antitumor effect was studied alone and in combination with anti-PD-1 immune checkpoint inhibition. Sensitization of this “cold” tumor to immune checkpoint inhibition after photoimmunotherapy would mean that the tumor has been converted into highly immunogenic, “hot” tumor infiltrated with… READ MORE
Related Modulight products and Services Related Publications Light emitting fabrics for PDT: technology and results of clinical studies Serge R. Mordon, Elise Thecua, Fabienne Lecomte, Anne-Sophie Vignion-Dewalle, Pascal Deleporte, Cyril Maire, Henry Abi-Rached, Claire Vicentini, Theresa Hommel, R. Markus Szeimies, Laurent Mortier SPIE, 2019 Photodynamic Therapy Using a New Painless Light-Emitting Fabrics Device in the Treatment of Extramammary Paget Disease of the Vulva (the PAGETEX Study):… READ MORE
Results Tumor growth was significantly suppressed by photoimmunotherapy, compared to control or IgG without light activation. Tumor growth suppression, as well as overall survival after photoimmunotherapy, were significantly better with F(ab´)2 fragments than with full IgG. This efficacy improvement might be related to killer T cells, which were detected in much higher numbers after photoimmunotherapy with F(ab´)2 fragments and are key cells for the generation of efficient systemic… READ MORE
Motivation for the study Polyps are small growths on the inner lining of the colon or rectum, affecting around 1 in 4 people over the age of 50. Certain types of polyps may eventually become cancerous, and colon cancer prevention relies on colonoscopy using white light to detect and remove the polyps. However, small and flat polyps are difficult to detect and frequently missed with this technique. More precise methods… READ MORE
Time: Wed 15.6.2016, 8:30–11:00 Place: Hotel Kämp, Helsinki Paavo Nurmi cabinet Pohjoisesplanadi 29, Helsinki, Finland Confirmed speakers Lecture slideshows Click here to view our previous workshop at ASLMS-2015. Related products: ML7710 – the tool for professionals » | Products for oncology » | ML8500 automatic illumination system » | Illumination kit »… READ MORE
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[slideshow_deploy id=’488′] Oncology Modulight laser systems are ideal solution for oncology, surgery & bacteria removal (photo disinfection). In Photodynamic therapy (PDT) alone – tens of hospitals use our systems. Our ML7710 is the most configurable laser platform in the world and boasts a unique platform approval. It boasts up to 8 channels, multiple wavelengths, tens of Watts optical power from 400 to 2000nm. All platform certification to accelerate your product… READ MORE