Tag Archives: fluorescence-guided surgery

Fluorescence-guided photoimmunotherapy for peritoneal carcinomatosis

Published in: SPIE BIOS 2024 Authors: Barry Liang, Sumiao Pang, Robert Perttilä, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron Sorrin, Nada Fadul, Idrisa Rahman, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang  Published in: SPIE BIOS 2024 Authors: Barry Liang, Sumiao Pang, Robert Perttilä, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron Sorrin, Nada Fadul, Idrisa Rahman, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang Peritoneal metastasis, incomplete resection, and drug resistance render advanced-stage ovarian cancer virtually incurable with current surgical and chemotherapy approaches. Photoimmunotherapy is increasingly used to treat unresectable metastases, but many innovations are lost in translation due to heterogeneous treatment effects. This study integrates targeted nanotechnology, fluorescence-guided intervention, and a medical laser system to Continue reading →

Fluorescence-guided photoimmunotherapy using targeted nanotechnology and ML7710 to manage peritoneal carcinomatosis

Published in: Science Advances Authors: Barry J. Liang(1,2), Sumiao Pang(1), Robert Perttilä(3), Chen-Hua Ma(1), Payal Srivastava(1), Brandon Gaitan(1), Aaron J. Sorrin (1), Nada Fadul(1), Zoe Ylöniemi(3), Dana M. Roque(4,5), Tayyaba Hasan(6), Petteri Uusimaa(3), Huang-Chiao Huang(1,4*) (1) Fischell Department of Bioengineering, University of Maryland (2) Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (3) Modulight Corp., Finland (4) Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine (5) Department of Obstetrics, Gynecology and Reproductive Sciences, University Continue reading →Published in: Science Advances Authors: Barry J. Liang(1,2), Sumiao Pang(1), Robert Perttilä(3), Chen-Hua Ma(1), Payal Srivastava(1), Brandon Gaitan(1), Aaron J. Sorrin (1), Nada Fadul(1), Zoe Ylöniemi(3), Dana M. Roque(4,5), Tayyaba Hasan(6), Petteri Uusimaa(3), Huang-Chiao Huang(1,4*) (1) Fischell Department of Bioengineering, University of Maryland (2) Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (3) Modulight Corp., Finland (4) Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine (5) Department of Obstetrics, Gynecology and Reproductive Sciences, University Continue reading →

Fluorescence-guided, targeted photochemotherapy of peritoneal carcinomatosis

Presented in: SPIE BIOS 2023 Authors: Barry J. Liang, Robert Perttilä, Sumiao Pang, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron J. Sorrin, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang    Presented in: SPIE BIOS 2023 Authors: Barry J. Liang, Robert Perttilä, Sumiao Pang, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron J. Sorrin, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang   Management of peritoneally metastatic cancer is a major clinical challenge. Peritoneal carcinomatosis is observed in 50% of colorectal cancer patients and >75% of ovarian cancer patients at the time of diagnosis. Selected patients based on age, comorbidities, and extent of the metastatic disease, will undergo complete cytoreductive surgery to remove the visible Continue reading →

ML7710 for glioblastoma treatment

Background   Professor Stummer on glioblastoma surgeries and iPDT:   Treatment protocol 20 patients were treated. 5-ALA (Gliolan) was administered at a dosage of 20 mg/kg body weight 4 hours before anesthesia. Craniotomy was performed using FGR, with aim of maximal safe resection of the fluorescent tumor. Once there was no visible fluorescence or only tumor-infiltrated fluorescence in the eloquent areas left, PDT was performed. 1-4 cylindrical diffuser were strategically inserted depending on the size and architecture of the resection cavity and fixed to a Continue reading →Customer case Research by: University Hospital Münster provides cutting-edge medical treatments for patients all over the world. The department of neurosurgery provides a full spectrum of neurosurgical care with interdisciplinary vascular and neuro-oncological specialization. Modulight products: ML7710, ML7710i Laser use: Randomized controlled PDT trials for both newly diagnosed and recurrent glioblastoma, as well as compassionate care for terminal glioblastoma patients. Link to the study: Professor Walter Stummer, MD, PhD Research topics: Professor Stummer is a world leader in his research fields, which include vascular neurosurgery, microneurosurgery, Continue reading →