Novel ophthalmic laser system paired with focal electroretinography for subthreshold laser therapy of DME

Presented in: SPIE BIOS 2023 Authors: Jukka-Pekka Alanko, Eero Koivumäki, Laura Vesala, Johannes Kivelä, Zoe Ylöniemi, Petteri Uusimaa, Ossi Kaikkonen, Teemu Turunen, Jaakko Nieminen, Jani Tirronen    Presented in: SPIE BIOS 2023 Authors: Jukka-Pekka Alanko, Eero Koivumäki, Laura Vesala, Johannes Kivelä, Zoe Ylöniemi, Petteri Uusimaa, Ossi Kaikkonen, Teemu Turunen, Jaakko Nieminen, Jani Tirronen   In the field of ophthalmic treatments, subthreshold laser therapy (SLT) has shown promise in addressing retinal diseases like diabetic macular edema (DME) and age-related macular degeneration (AMD). However, the precise control of therapeutic temperatures is challenging due to variations in individual eye characteristics. Modulight and Maculaser have addressed this issue with their innovative ML6710i device. This device utilizes a combination of laser beams to achieve precise thermal Continue reading →

Laser platform and light delivery optimization for bladder cancer treatment with a novel photosensitive drug

Presented in: SPIE BIOS 2023 Authors: Zoe Ylöniemi, Elias Kokko, Visa Kaivosoja, Ana Colucci, Eerika Suokas, Jukka-Pekka Alanko, Petteri Uusimaa, Modulight Corp.    Presented in: SPIE BIOS 2023 Authors: Zoe Ylöniemi, Elias Kokko, Visa Kaivosoja, Ana Colucci, Eerika Suokas, Jukka-Pekka Alanko, Petteri Uusimaa, Modulight Corp.   Non-muscle invasive bladder cancer (NMIBC) is a form of cancer with a relatively high 5-year survival rate but also very high recurrence rate. Photodynamic diagnosis is commonly used in standard clinical practice to visualize bladder cancer lesions as part of a TURBT procedure but photodynamic treatments utilizing photosensitive drugs have had limited success in clinical setting partly because of limitations in light Continue reading →

Novel ophthalmic PDT laser platform to target oncology and various other retinal indications

Presented in: SPIE BIOS 2023 Authors: Laura Vesala, Eero Koivumäki, Jukka-Pekka Alanko, Timo Tanila, Ivan Baldin, Zoe Ylöniemi, Petteri Uusimaa, Modulight Corp.    Presented in: SPIE BIOS 2023 Authors: Laura Vesala, Eero Koivumäki, Jukka-Pekka Alanko, Timo Tanila, Ivan Baldin, Zoe Ylöniemi, Petteri Uusimaa, Modulight Corp.   Laser systems, in ophthalmic applications, are utilized in the treatment of various ophthalmic diseases such as in ocular oncology and age-related macular degeneration through photochemical mechanism of photodynamic therapy. In addition, these lasers can be used to activate drug delivery systems in the retina to provide targeted drug therapy. PDT is a form of a combination treatment which utilizes light energy to Continue reading →

Configurable multiwavelength narrow linewidth laser system for quantum applications

Presented in: SPIE Quantum West 2023 Authors: Kostiantyn Nechay, Luukas Kuusela, Ossi Mäkinen, Riina Ulkuniemi, Pekko Sipilä, Kalle Palomäki, Petteri Uusimaa    Presented in: SPIE Quantum West 2023 Authors: Kostiantyn Nechay, Luukas Kuusela, Ossi Mäkinen, Riina Ulkuniemi, Pekko Sipilä, Kalle Palomäki, Petteri Uusimaa   Single-frequency laser sources serve as a backbone for quantum computing and metrology technologies and applications. Availability of integrated laser systems delivering tailored multiwavelength emission across optical spectrum is a defining factor for further quantum technologies development and commercialization. Modulight demonstrates highly integrated ML6600 laser system for cooling and repumping of 87Rb atoms at D2 line. Such laser system incorporates driving electronics, internal spectroscopy-locked Continue reading →

Optimization and fabrication of 780 nm DFB lasers for quantum systems

Presented in: SPIE Quantum West 2023 Authors: Riina Ulkuniemi, Luukas Kuusela, Timo Aho, Petteri Uusimaa    Presented in: SPIE Quantum West 2023 Authors: Riina Ulkuniemi, Luukas Kuusela, Timo Aho, Petteri Uusimaa   Laser diode solutions for quantum systems have highly variable requirements, depending on the technology and purpose of the laser used in the application – for instance, quantum control of particles or molecules and excitation of the quantum systems. Requirements of the laser systems used in the mentioned applications are highly demanding, such as single-mode operation, frequency stability over operation lifetime and narrow spectral linewidth. Narrow spectral linewidth can be achieved with Continue reading →

High aspect ratio DBR gratings for narrow linewidth red lasers

Presented in: SPIE Quantum West 2023 Authors: Luukas Kuusela, Riina Ulkuniemi, Timo Aho, Petteri Uusimaa    Presented in: SPIE Quantum West 2023 Authors: Luukas Kuusela, Riina Ulkuniemi, Timo Aho, Petteri Uusimaa   In interferometry, spectroscopy, and holography, HeNe lasers or semiconductor lasers with external wavelength stabilization have been widely used to achieve the required narrow linewidth at 633 nm. Semiconductor lasers utilizing wavelength selective grating fabricated on semiconductor chip enable the miniaturization of laser systems while also providing numerous advantages such as low energy consumption, reliability and tunability by temperature and injection current. Moreover, DBR gratings reduce the complexity of the laser system compared Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – February 2023

 Modulight Spotlights: LASER-SHARP RESEARCH – February 2023 The nomination for Laser-Sharp Research goes to Mäki-Mikola et al. at University of Helsinki for their development of a dynamic cell culturing platform for light-activation studies. The developed platform has a flow chamber connected to a peristaltic pump, which creates a flow that resembles the natural fluid flow at the cell surfaces. ML6500 laser was used to release calcein from liposomes to validate the suitability of the platform for light-triggered drug release. Compared to traditional static cell culture Continue reading →

Bausch + Lomb and Modulight Announce FDA Approval of ML6710i Photodynamic Laser for Use with Bausch + Lombs VISUDYNE (Verteporfin for Injection)

Bausch + Lomb and Modulight Announce FDA Approval of ML6710i Photodynamic Laser for Use with Bausch + Lomb’s VISUDYNE® (Verteporfin for Injection) VAUGHAN, Ontario and TAMPERE, Finland, Feb. 1, 2023 – Bausch + Lomb Corporation (NYSE/TSX: BLCO) (“Bausch + Lomb”), a leading global eye health company dedicated to helping people see better to live better, and Modulight Corporation (“Modulight”), a biomedical laser company, today announced that the U.S. Food and Drug Administration (FDA) has approved the ML6710i photodynamic laser for equivalent use with Bausch + Lomb’s VISUDYNE® (verteporfin for injection) photodynamic therapy (PDT) for the treatment Continue reading →Modulight Investor Contacts: Ulla Haapanen ulla.haapanen@modulight.com (408) 218-7960 Modulight Media Contacts: Zoe Ylöniemi zoe.yloniemi@modulight.com (408) 239-3488 Bausch + Lomb Investor Contacts: Arthur Shannon/Allison Ryan arthur.shannon@bausch.com allison.ryan@bausch.com (877) 354-3705 (toll free); (908) 927-0735 Bausch + Lomb Media Contacts: Lainie Keller/Kristy Marks lainie.keller@bausch.com kristy.marks@bausch.com (908) 927-1198; (908) 927-0683 Bausch + Lomb and Modulight Announce FDA Approval of ML6710i Photodynamic Laser for Use with Bausch + Lomb’s VISUDYNE® (Verteporfin for Injection) VAUGHAN, Ontario and TAMPERE, Finland, Feb. 1, 2023 – Bausch + Lomb Corporation (NYSE/TSX: BLCO) (“Bausch + Lomb”), a leading global Continue reading →

Modulight Geographic Expansion Continues in Europe with Laser 2000

PALO ALTO, CALIFORNIA & TAMPERE, FINLAND, 26TH JANUARY 2023 – Modulight Corp., a biomedical & semiconductor laser manufacturer, is expanding sales in Europe through a distribution partnership with Laser 2000, a pan European solutions provider for lasers and photonics since 1986. The exclusive partnership with Laser 2000 brings Modulight’s products available to customers in Germany, Austria, Switzerland, and France. Laser 2000 customers include several of the biggest technology companies in Europe. The expectation is that this collaboration with Laser 2000 will open significant sales opportunities Continue reading →PALO ALTO, CALIFORNIA & TAMPERE, FINLAND, 26TH JANUARY 2023 – Modulight Corp., a biomedical & semiconductor laser manufacturer, is expanding sales in Europe through a distribution partnership with Laser 2000, a pan European solutions provider for lasers and photonics since 1986. The exclusive partnership with Laser 2000 brings Modulight’s products available to customers in Germany, Austria, Switzerland, and France. Laser 2000 customers include several of the biggest technology companies in Europe. The expectation is that this collaboration with Laser 2000 will open significant sales opportunities Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – December 2022

   Modulight Spotlights: LASER-SHARP RESEARCH – December 2022 This month’s research spotlight goes to H. Wakiyama, H. Kobayashi, et al. at National Cancer Institute, USA. Their study, published in Cancer Immunology Research journal, looked into immunological mechanisms behind hyperprogressive disease. Immune checkpoint inhibitors, despite being a major success story in the field of cancer therapy, unfortunately lead to this rapid progression of cancer in some patients, for yet poorly understood reasons. To study this, the research team partially depleted cytotoxic T cells by photoimmunotherapy, using CD8-targeted Continue reading →