Modulight Spotlights: LASER-SHARP RESEARCH – January 2024 Phototherapy is widely established treatment for skin diseases like actinic keratosis, cutaneous infections, and skin tumors, resulting in excellent cosmetic outcomes. However, some clinically used light sensitizing drugs have drawbacks such as limited penetration depth and high painfulness to patient. In a new study by Andreea Burloiu and the teams at Carol Davila University of Medicine and Pharmacy, new photoactivated drugs were developed for treatment of skin diseases. ML6600 laser with MLAKIT was used to evaluate the effect
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Published in: OPTO SPIE 2024 Authors: Andreas Schramm, Luukas Kuusela, Mika Mähönen, Soile Talmila, Ville Vilokkinen, Petteri Uusimaa Published in: OPTO SPIE 2024 Authors: Andreas Schramm, Luukas Kuusela, Mika Mähönen, Soile Talmila, Ville Vilokkinen, Petteri Uusimaa We report on tailoring capabilities in the 7xx nm wavelength range utilizing GaAsP or InGaAsP quantum wells (QW) embedded in AlGaAs. Laser structures are grown using metal-organic chemical vapor deposition. Wafers and manufactured lasers are thoroughly characterized, and lifetime tests are performed to validate laser reliabilities. Changing QW parameters enables us to tune the wavelength or polarization of the laser emission. Read the article here
Published in: SPIE BIOS 2024 Authors: Henri Auvinen, Lassi Luokkanen, Zoe Ylöniemi, Natalia Leinonen, Ana Colucci, Petteri Uusimaa Published in: SPIE BIOS 2024 Authors: Henri Auvinen, Lassi Luokkanen, Zoe Ylöniemi, Natalia Leinonen, Ana Colucci, Petteri Uusimaa Monitoring treatment through spectral data enables adjusting treatment in real-time for each patient separately, in line with the trend for personalized medicine. Modulight ML7710 laser can simultaneously measure spectral data from up to 8 different locations in tumor tissue. The laser with this optical monitoring feature is currently being tested in glioblastoma trials in Germany where patients receive photoimmunotherapy and treatment is tailored through spectral monitoring of
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Fully vertically integrated laser fabWe encompass a comprehensive spectrum of functions related to laser design and manufacturing. Our comprehensive in-house expertise spans across all laser technologies, including fiber lasers, VCSELs, VECSELs, DBRs, and solid-state lasers. All this is built in ready-to-use laser modules and systems, equipped with intuitive user interfaces.Modulight's State-of-the-Art Fab in Tampere, Finland Modulight’s 62,000 sq ft headquarters are located in Tampere, Finland. Fully vertically integrated fab is equipped with offices, laboratories, and world-class cleanrooms. 10,000 sq ft is dedicated to ISO 5
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Introduction to DRB lasers Distributed Bragg Reflector (DBR) laser diodes are a class of single-frequency monolithic semiconductor lasers. Monolithic semiconductor lasers in general are small in size, mechanically robust, and have good power conversion efficiency. They also provide opportunities for hybrid integration with photonic integrated circuits (PICs). This application note provides an overview of DBR lasers, their principles of operation, their modal behavior, and their diverse applications. Principles of DBR Laser Operation A DBR laser is a semiconductor laser with one or several quantum wells
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Modulight Spotlights: LASER-SHARP RESEARCH – December 2023 Organic compounds are one of the leading causes of water pollution. Rhodamine 6G is a commonly used dye in the food and textile industries and can cause cancer when consumed in contaminated water. To tackle this problem, Professor T. Nyokong’s team at Rhodes University studied photocatalysis with ML7710 for degrading rhodamine, and showed increased degradation efficiency when photocatalysis was combined with ultrasound (sonocatalysis). This Laser-Sharp study offers a new method for more efficient degradation of organic pollutants for environmental
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Modulight Spotlights: LASER-SHARP RESEARCH – November 2023 The development of modern antibiotics is recognized as one of the major achievements of medicine and has saved millions of lives. However, many infectious agents have developed resistance to antibiotics over time, and defining new antibiotic targets has been difficult since very few genes are essential for pathogens. To combat this growing problem, Professor Timothy Haystead’s team at Duke University developed a novel light-based antimicrobial strategy that targets non-essential enzyme on the surface of bacteria. Light activation was
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Modulight Spotlights: LASER-SHARP RESEARCH – October 2023 Antimicrobial resistance is an increasing healthcare problem, with new effective treatment strategies urgently needed. Professor Mitsunaga and team at The Jikei University Medical School, Japan, describe a promising treatment called photoimmuno-antimicrobial strategy (PIAS) in a new Nature publication. Detailed instructions how to design and implement the treatment are given, with Modulight’s ML7710 and ML6600 series lasers validated for drug activation in the protocol. This treatment enables targeted elimination of different microbes, regardless of the species or drug resistance
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Modulight Spotlights: LASER-SHARP RESEARCH – September 2023 Head & neck cancer is world’s sixth most common cancer, with increasing incidence and poor survival. A new study by P. Enzian & R. Rahmanzadeh at University of Lübeck, studied combining chemotherapy with photochemical internalization for more effective H&N cancer treatment in vitro. Photochemical internalization using photosensitizer fimaporfin, activated with Modulight’s ML6600 laser, was shown to increase drug’s efficacy by means of better drug delivery inside the cells. As a result, tumor cell death was achieved using 20-fold
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Modulight Spotlights: LASER-SHARP RESEARCH – August 2023 Interleukin 15 (IL-15) is promising candidate for cancer immunotherapy, since it is an inducer of differentiation and proliferation of killer T cells and NK cells. A new study by Fukushima et al. at NCI, published in Molecular Cancer Therapeutics, shows increase in therapeutic efficacy in vivo when IL15 was combined with photoimmunotherapy using ML7710 laser system. Intratumoral injection of IL-15 also boosted the immune responses against both the primary tumor as well as abscopal effect eradicating distant, untreated tumor. Read original publication Modulight
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