High-power VECSEL with intracavity UV generation for flow cytometry applications

Published in: SPIE BIOS 2024 Authors: Kostiantyn Nechay, Robert Perttilä, Anna Essaulova, Petteri Uusimaa  Published in: SPIE BIOS 2024 Authors: Kostiantyn Nechay, Robert Perttilä, Anna Essaulova, Petteri Uusimaa Flow cytometry is a powerful tool allowing to perform high-dimensional cell analysis which relies on a set of lasers for fluorochrome excitation. Typical flow cytometer employs excitation laser sources at violet, green, green-yellow and red wavelengths, with an extension to UV and DUV spectral bands in order to increase the number of cell characteristics. UV laser source constitutes the single most expensive component of flow cytometers. In this work we present Continue reading →

Fluorescence-guided photoimmunotherapy for peritoneal carcinomatosis

Published in: SPIE BIOS 2024 Authors: Barry Liang, Sumiao Pang, Robert Perttilä, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron Sorrin, Nada Fadul, Idrisa Rahman, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang  Published in: SPIE BIOS 2024 Authors: Barry Liang, Sumiao Pang, Robert Perttilä, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron Sorrin, Nada Fadul, Idrisa Rahman, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang Peritoneal metastasis, incomplete resection, and drug resistance render advanced-stage ovarian cancer virtually incurable with current surgical and chemotherapy approaches. Photoimmunotherapy is increasingly used to treat unresectable metastases, but many innovations are lost in translation due to heterogeneous treatment effects. This study integrates targeted nanotechnology, fluorescence-guided intervention, and a medical laser system to Continue reading →

Modulight launches ML6600 for Flow Cytometry and Quantum Computing

Next week at Photonics West 2024, Modulight will unveil significant new additions to the ML6600 laser solution platform. These new innovations include a specialized laser engine tailored for Flow Cytometry applications, and advanced DBR laser cores designed specifically for the Quantum Computing market. Our #LaserFamily are presenting 11 conference papers plus participating in a technical panel, across the Photonics West conferences BIOS, OPTO, LASE and QUANTUM WEST. You can see the list here. ML6600 for Flow Cytometry – Laser engine with active beam steering The newest product utilizing the ML6600 platform is a specialized laser engine for the Continue reading →Next week at Photonics West 2024, Modulight will unveil significant new additions to the ML6600 laser solution platform. These new innovations include a specialized laser engine tailored for Flow Cytometry applications, and advanced DBR laser cores designed specifically for the Quantum Computing market. Our #LaserFamily are presenting 11 conference papers plus participating in a technical panel, across the Photonics West conferences BIOS, OPTO, LASE and QUANTUM WEST. You can see the list here. ML6600 for Flow Cytometry – Laser engine with active beam steering The newest product utilizing the ML6600 platform is a specialized laser engine for the Continue reading →

Biolab

Modulight biomedical laboratoriesWe're at the forefront of driving customer research and development. Our expertise is your fast track to market success, whether you're developing groundbreaking cancer drugs, harnessing laser technology, or conducting in-depth in vitro studies with cancer cell lines. Backed by a multidisciplinary team of engineers, biotechnology experts, and medical professionals, we're here to guide your journey.Modulight's BIOLAB at your service General biomedical laboratory Fluorescence feasibility studies of current and novel photosensitizer drugs, absorbance and emission spectra measurements and fluorescence imaging Optical phantom studies Continue reading →

Pioneering study confirms benefits of Modulight’s technology and photoimmunotherapy for ovarian cancer

A study published in Science Advances has for the first time scientifically demonstrated the potential of fluorescence-guided photoimmunotherapy enabled with Modulight’s laser platform and cloud technology. The study, a collaboration between the University of Maryland (UMD) and Modulight, confirms the benefits of targeted nanomedicine, Modulight’s medical laser system, and fluorescence-guided intervention in both achieving better treatment outcomes and predicting tumor response. “We have already published over a hundred scientific articles on our website from world-leading research groups that have used Modulight products in their studies. This Continue reading →A study published in Science Advances has for the first time scientifically demonstrated the potential of fluorescence-guided photoimmunotherapy enabled with Modulight's laser platform and cloud technology. The study, a collaboration between the University of Maryland (UMD) and Modulight, confirms the benefits of targeted nanomedicine, Modulight’s medical laser system, and fluorescence-guided intervention in both achieving better treatment outcomes and predicting tumor response. "We have already published over a hundred scientific articles on our website from world-leading research groups that have used Modulight products in their studies. This Continue reading →

Fluorescence-guided photoimmunotherapy using targeted nanotechnology and ML7710 to manage peritoneal carcinomatosis

Published in: Science Advances Authors: Barry J. Liang(1,2), Sumiao Pang(1), Robert Perttilä(3), Chen-Hua Ma(1), Payal Srivastava(1), Brandon Gaitan(1), Aaron J. Sorrin (1), Nada Fadul(1), Zoe Ylöniemi(3), Dana M. Roque(4,5), Tayyaba Hasan(6), Petteri Uusimaa(3), Huang-Chiao Huang(1,4*) (1) Fischell Department of Bioengineering, University of Maryland (2) Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (3) Modulight Corp., Finland (4) Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine (5) Department of Obstetrics, Gynecology and Reproductive Sciences, University Continue reading →Published in: Science Advances Authors: Barry J. Liang(1,2), Sumiao Pang(1), Robert Perttilä(3), Chen-Hua Ma(1), Payal Srivastava(1), Brandon Gaitan(1), Aaron J. Sorrin (1), Nada Fadul(1), Zoe Ylöniemi(3), Dana M. Roque(4,5), Tayyaba Hasan(6), Petteri Uusimaa(3), Huang-Chiao Huang(1,4*) (1) Fischell Department of Bioengineering, University of Maryland (2) Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (3) Modulight Corp., Finland (4) Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine (5) Department of Obstetrics, Gynecology and Reproductive Sciences, University Continue reading →

Intratumoral interleukin-15 improves efficacy of near-infrared photoimmunotherapy

Published in: Molecular Cancer Therapeutics Authors: Hiroshi Fukushima, Aki Furusawa, Takuya Kato, Hiroaki Wakiyama, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi    Published in: Molecular Cancer Therapeutics Authors: Hiroshi Fukushima, Aki Furusawa, Takuya Kato, Hiroaki Wakiyama, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi   Interleukin 15 (IL-15) is inducer of differentiation and proliferation of CD8+ T cells and NK cells and thus promising candidate for cancer immunotherapy. This study showed therapeutic efficacy increase in vivo when IL15 was combined with cancer cell-targeted photoimmunotherapy using ML7710 laser system. Intratumoral injection of IL-15 was more effective than intraperitoneal in suppressing tumor growth and inducing intratumoral immune responses, Continue reading →

World Congress organized by Modulight and the International Photodynamic Association brings world leading experts in Photodynamic therapy to Tampere

During this week, Tampere Hall will be filled with experts and scientists in photodynamic therapy as the international congress organized by Modulight gets underway. The biennial congress, the scientific content of which are carefully screened by the International Photodynamic Association (IPA), will give medical researchers, and doctors the opportunity to share their ideas, research results and new discoveries in the field of medicine and technology. The congress, which starts on Monday 10 July, will be opened by Anna-Kaisa Ikonen, Minister of Local Government of Finland, Continue reading →During this week, Tampere Hall will be filled with experts and scientists in photodynamic therapy as the international congress organized by Modulight gets underway. The biennial congress, the scientific content of which are carefully screened by the International Photodynamic Association (IPA), will give medical researchers, and doctors the opportunity to share their ideas, research results and new discoveries in the field of medicine and technology. The congress, which starts on Monday 10 July, will be opened by Anna-Kaisa Ikonen, Minister of Local Government of Finland, Continue reading →

Transient fluid flow improves photoimmunoconjugate delivery and photoimmunotherapy efficacy

Published in: iScience Authors: Aaron J. Sorrin, Keri Zhou, Katherine May, Cindy Liu, Kathryn McNaughton, Idrisa Rahman, Barry J. Liang, Imran Rizvi, Dana M. Roque, Huang-Chiao Huang    Published in: iScience Authors: Aaron J. Sorrin, Keri Zhou, Katherine May, Cindy Liu, Kathryn McNaughton, Idrisa Rahman, Barry J. Liang, Imran Rizvi, Dana M. Roque, Huang-Chiao Huang   The study showed that fluid flow induced shear stress increased the photocytotoxicity of different photosensitizers tested (BPD, PIC, PIC-coated liposome) against ovarian cancer cells. The cellular delivery of photosensitizers doubled compared to static conditions. Modulight laser was used for PDT activation together with photosensitizer(s). Circulating drugs in the peritoneal cavity is an effective strategy for advanced ovarian Continue reading →

Fluorescence endoscopy

Fluorescence endoscopyFluorescence endoscopy is the latest advancement in endoscopy technology, which uses specialized dyes to highlight specific areas of interest and provide better visibility and image quality during procedures. This technology has revolutionized the way we view the inside of the body, enabling doctors to obtain more detailed images of the gastrointestinal tract, lungs, bladder, and reproductive organs.Endoscopy Endoscopy is a powerful tool in diagnosing and treating a wide range of medical conditions. With its minimally invasive approach and high accuracy, it has become a Continue reading →